Well, it should come as no surprise that I haven't read any Hemingway either. It seems his suicide has captured every one's attention and I guess because mom and I are teaching this Bringing Up Boys class I was reminded of Hemingway's very poor relationship with his father. Probably had as much to do with his difficult life, if not more, than his creative streak.
I, however, have read Lost In the Cosmos (thanks Amber) and I'm inclined to echo Amber's thoughts on the artist's struggle. Actually, if I remember correctly, it is a problem for more than just artists, but for anyone who seems to (and here's a connection to our appearance/reality discussion) connect to reality in some unusual way and then tries to "re-enter" life.
Numbers had several interesting episodes about this topic when Dr. Larry Fleinhardt experienced real difficulty "returning" to earth after his space shuttle mission. He was struggling with a lot of life's BIG questions, entered a Buddhist monastery, etc., etc. etc.
Lost In The Cosmos is definitely a good read.
Dad